My research focuses on genes, which interact with male sex determining gene Sry, its target Sox9 and others to coordinate Sertoli and Leydig cell differentiation in the fetal testis. Any abnormality in this critical development process may lead to infretility or serious reproductive diseases in male humans. Exposure of mother to environmental stressors may affect development of fetal organs, which may lead to serious diseases in that individual at adulthood, which is also called "Fetal origin of adult disease". Moreover, some adult diseases of fetal origin are likely transmit to subsequent generation through germ line transmission. I am striving for finding some molecular biomarkers that detect abnormalities in fetal development that turns out to be disease at the adulthood.